| Drug to treat Parkinson's disease | 37 |
| Drug that's smoked in a pipe | 32 |
| Drug that's only smoked in pictures? | 40 |
| Drug that's affiliated with anxietyinfo.com | 47 |
| Drug that was dropped in the '60s | 37 |
| Drug that might cause flashbacks | 32 |
| Drug that may keep you up for days? | 35 |
| Drug that is, ironically, inhaled | 33 |
| Drug that can cause memory blackouts, in slang | 46 |
| Drug that can cause an acid trip | 32 |
| Drug that calms the nerves, slangily | 36 |
| Drug tester's control substance | 35 |
| Drug source for ancient executions | 34 |
| Drug sold under the brand name Retrovir | 39 |
| Drug smuggler's measures, perhaps | 37 |
| Drug once tested extensively by CIA employees | 45 |
| Drug once derived from willow bark | 34 |
| Drug often advertised in e-mail spam | 36 |
| Drug introduced commercially in 1945 | 36 |
| Drug initially studied for use in treating angina | 49 |
| Drug in a Miley Cyrus viral video | 33 |
| Drug in "Brave New World" | 35 |
| Drug in "Apocalypse Now" | 34 |
| Drug given to race horses, for short | 36 |
| Drug giant behind Valium and Klonopin | 37 |
| Drug for Parkinson's patients | 33 |
| Drug dealer on "The Wire" | 35 |
| Drug company once headed by Donald Rumsfeld | 43 |
| Drug company giant that makes Coppertone | 40 |
| Drug brand name that combines Latin words | 41 |
| Drug at the center of some 19th-century wars | 44 |
| Drug associated with Miley Cyrus | 32 |
| Drug associated with feelings of strength | 41 |
| Drug also known as "ozone" | 36 |
| Drug abused by Rush Limbaugh and Courtney Love | 46 |
| Drug "dropped" in the '60s | 40 |
| Drs. who may appreciate the quip | 32 |
| Droxies used to compete with them | 33 |
| Drowning Pool song we feel sorry for? | 37 |
| Drowning Pool single off eponymous album | 40 |
| Drove on a course, with "off" | 39 |
| Drove a Phillips-head into a bowl of borscht? | 45 |
| Drought-damaged (hidden in SERENA WILLIAMS) | 43 |
| Drops the equipment at the club before a gig | 44 |
| Drops on the playing field, perhaps | 35 |
| Drops of golden sun, on music scales | 36 |
| Drops like balls in a bad juggling act? | 39 |
| Drops in summertime temperatures? | 33 |
| Drops in a box on the street, say | 33 |
| Dropping, in a manner of speaking | 33 |
| Dropping off the dry cleaning, e.g. | 35 |
| Dropping of a vowel in pronunciation | 36 |
| Dropping it might get you arrested | 34 |
| Dropping it in public may cause a scene | 39 |
| Dropped-donut reaction for Homer | 32 |
| Dropped to the bottom of the lake | 33 |
| Dropped thing that can turn heads | 33 |
| Dropped part of rapper Bow Wow's name | 41 |
| Dropped in somewhere along the way | 34 |
| Dropped flies and bad throws, in baseball | 41 |
| Dropped back after a promising start | 36 |
| Dropout's goal, perhaps: Abbr. | 34 |
| Dropkick Murphys "Bloody Pig ___" | 43 |
| Drop-down item that hopefully doesn't have to | 49 |
| Drop ___ (skydiver's target) | 32 |
| Drop __ (announce startling news) | 33 |
| Drop trou while standing on a pier? | 35 |
| Drop tower or whirling teacups, e.g. | 36 |
| Drop the ___ (admit one's love, slangily) | 45 |
| Drop the ball, literally or figuratively | 40 |
| Drop that rolls down one's cheek | 36 |
| Drop out of school for millions, perhaps | 40 |
| Drop off at FedEx Office, perhaps | 33 |
| Drop from the invitation list, say | 34 |
| Drop a modern-day line to, perhaps | 34 |
| Drop a hip-hop star from the festival lineup? | 45 |
| Drooping, as a rabbit's ears | 32 |
| Drooling pooch in "Garfield" | 38 |
| Drooling dog in "Garfield" | 36 |
| Droll actor in "Ghostbusters" | 39 |
| Droid salesmen in "Star Wars" | 39 |
| Droid in every "Star Wars" film | 41 |
| Droid in all the "Star Wars" films | 44 |
| Droid in all six "Star Wars" films | 44 |
| Driving-school students, usually | 32 |
| Driving-directions listings: Abbr. | 34 |
| Driving is hard when this is driving | 36 |
| Driving instructor's command | 32 |
| Driving events that use checkpoints | 35 |
| Driving distance is a concern in it | 35 |
| Drives with the tach above the recommended limit | 48 |
| Drives in the back seat of a car? | 33 |
| Drives in reverse, with "up" | 38 |
| Drives directly to the final destination? | 41 |
| Drives a truck full of batteries? | 33 |
| Drivers' organization, familiarly | 37 |
| Drivers' and divers' facilities | 39 |
| Drivers use it to get to the bank? | 34 |
| Drivers of some slow-moving vehicles | 36 |
| Drivers of red-white-and-blue vans | 34 |