| Makes safe for drinking, as water | 33 |
| Makes sense (with "up") | 33 |
| Makes sense, with "up" | 32 |
| Makes some music, like the Stones | 33 |
| Makes some shocking macaroni art, perhaps? | 42 |
| Makes some Web-site edits, maybe | 32 |
| Makes something better in a big way | 35 |
| Makes something better, big-time | 32 |
| Makes sure of, with "it" | 34 |
| Makes the first row of stitches in knitting | 43 |
| Makes the line longer, so to speak | 34 |
| Makes the minimum purchase at the dollar store? | 47 |
| Makes the opening speech at a convention | 40 |
| Makes things interesting, in a way | 34 |
| Makes too many wrong turns, maybe | 33 |
| Makes wet and dirty, as from rain | 33 |
| Makeshift beach blanket Othello piece? | 38 |
| Makeshift hiding place during a sleepover | 41 |
| Makeup artist who wrote "Making Faces" | 48 |
| Makeup of "the old ball game" | 39 |
| Makeup of Keats's "Endymion" | 42 |
| Makeup of men who can't stand the heat? | 43 |
| Makeup of some gems and wristwatches | 36 |
| Makeup of some high-end bike frames | 35 |
| Makeup of some insulating sheets | 32 |
| Makeup of some mortars and pestles | 34 |
| Makeup of the "Game of Thrones" throne | 48 |
| Makeup of underwater "forests" | 40 |
| Makeup of WWII's "mosquito fleet" | 47 |
| Makeup remover that's selling like mad | 42 |
| Makin' mistakes on the sitar? | 33 |
| Making a 60-yard field goal, e.g. | 33 |
| Making a big profit, with "up" | 40 |
| Making a blunder (and this puzzle's theme) | 46 |
| Making a note of, with "down" | 39 |
| Making a profit on Broadway, in a way | 37 |
| Making all your beer the night before? | 38 |
| Making beds and dusting, for a maid | 35 |
| Making daguerreotypes, and other things | 39 |
| Making distinctions of little importance | 40 |
| Making Kool-Aid with holy water, e.g. | 37 |
| Making lots of circles in a cartoon? | 36 |
| Making love to the camera, so to speak | 38 |
| Making more guns and less butter? | 33 |
| Making off with an old video game? | 34 |
| Making one's way down the corporate ladder? | 47 |
| Making out in front of everyone, say, for short | 47 |
| Making out in public, e.g.: Abbr. | 33 |
| Making progress according to schedule | 37 |
| Making sure you have all the parts, e.g. | 40 |
| Making the dean's list, e.g. | 32 |
| Making the rounds, as an officer | 32 |
| Makings of a very boring mosaic? | 32 |
| Malady in the film "Vertigo" | 38 |
| Malady named after a Connecticut town | 37 |
| Malady that might cause blurred vision | 38 |
| Malady that typically worsens in the spring | 43 |
| Malagasy Republic's alternate name | 38 |
| Malaise, with ''the'' | 37 |
| Malamud novel (with "The") | 36 |
| Malamud novel, with "The" | 35 |
| Malaria-fighting compound during W.W. II | 40 |
| Malay Peninsula's Isthmus of __ | 35 |
| Malay Peninsula's Isthmus of ___ | 36 |
| Malaysian Chinese shoe designer Jimmy | 37 |
| Malcolm X, for Denzel Washington | 32 |
| Malcolm's "The Cosby Show" role | 45 |
| Malcolm-Jamal's "Cosby Show" role | 47 |
| Malcolm-__ Warner of "The Cosby Show" | 47 |
| Malden of ''Patton'' | 36 |
| Malden's employer in a '70s TV series | 45 |
| Male actor with the most performing Emmys | 41 |
| Male ballroom dancer, traditionally | 35 |
| Male breakdancer with a feminine sobriquet? | 43 |
| Male cartoon character voiced by Nancy Cartwright | 49 |
| Male character in French pantomime | 34 |
| Male elephant seal, in mating season | 36 |
| Male escorts working alone? (goes both ways) | 44 |
| Male fashion of Washington's time | 37 |
| Male friend or relative, in slang | 33 |
| Male friend, south of the border | 32 |
| Male goose during hunting season? | 33 |
| Male half of the McGraw-Hill union | 34 |
| Male horse parts rendered useless? | 34 |
| Male lead in "Carousel": 1945 | 39 |
| Male name that spells another male name backward | 48 |
| Male offspring with 20 fingers each? | 36 |
| Male seals' group of devotees | 33 |
| Male Shakespeare role sometimes played by a woman | 49 |
| Male singer for whom the Italians used to go nuts | 49 |
| Male star of "Three's Company" | 44 |
| Male Supreme Court Justice, assuredly | 37 |
| Malfoy's look, in the Harry Potter books | 44 |
| Malfunction, with "up" | 32 |
| Malfunctioning candy dispensers? | 32 |
| Malfunctioning wildly, as a computer | 36 |
| Malia's sister in the White House | 37 |
| Maliciously burn a complimentary ticket? | 40 |
| Maligned clear drink of the 1990s | 33 |
| Mall chain, with "The" | 32 |