| Spike or Bruce | 14 |
| Spike or Pinky | 14 |
| Spike or Robert E. | 18 |
| Spike or Sir Christopher | 24 |
| Spike or Stinky | 15 |
| Spike preceder, in volleyball | 29 |
| Spike setup | 11 |
| Spike sued to prevent its name change | 37 |
| Spike that tried to sue Spike TV | 32 |
| Spike the Beanie Baby, e.g. | 27 |
| Spike the director | 18 |
| Spike the punch | 15 |
| Spike the punch anew | 20 |
| Spike to shuck | 14 |
| Spike TV's former name | 26 |
| Spike TV's old name | 23 |
| Spike TV, formerly | 18 |
| Spike TV, once | 14 |
| Spike TV, previously | 20 |
| Spike who co-directed the video for Kanye's "Flashing Lights" | 75 |
| Spike who directed "Crooklyn" | 39 |
| Spike who's a Knicks fan | 28 |
| Spike with a joint? | 19 |
| Spike with an eye | 17 |
| Spike's bowlful | 19 |
| Spike's bowlful, perhaps | 28 |
| Spike's former name | 23 |
| Spike's greeting | 20 |
| Spike's old letters | 23 |
| Spike's old network name | 28 |
| Spike's relative | 20 |
| Spike's victim, in "Nancy" comics | 47 |
| Spike, as a drink | 17 |
| Spike, as of grain | 18 |
| Spike, as punch | 15 |
| Spike, as the punch | 19 |
| Spike, before it was Spike TV | 29 |
| Spike, for one | 14 |
| Spike, notably | 14 |
| Spike, once | 11 |
| Spike, previously | 17 |
| Spike, the director | 19 |
| Spike/Harper | 12 |
| Spikeable Christmas drink | 25 |
| Spiked | 6 |
| Spiked a drink | 14 |
| Spiked cake | 11 |
| Spiked cakes | 12 |
| Spiked club | 11 |
| Spiked club of feudal times | 27 |
| Spiked clubs | 12 |
| Spiked dessert | 14 |
| Spiked honey beverage | 21 |
| Spiked implement | 16 |
| Spiked OJ | 9 |
| Spiked part of a stegosaurus | 28 |
| Spiked punch? | 13 |
| Spiked shield boss | 18 |
| Spiked staff | 12 |
| Spiked staffs | 13 |
| Spiked the punch | 16 |
| Spiked weapons | 14 |
| Spiked wheel on a spur | 22 |
| Spiked, as a beverage | 21 |
| Spiked, as party punch | 22 |
| Spiked, as punch | 16 |
| Spiked, like punch | 18 |
| Spikelike formation | 19 |
| Spikelike inflorescence | 23 |
| Spikelike tool | 14 |
| Spiker's barrier | 20 |
| Spikes | 6 |
| Spikes a drink | 14 |
| Spikes are common in it | 23 |
| Spikes for Hillary | 18 |
| Spikes for walking on ice | 25 |
| Spikes on a farm | 16 |
| Spikes taken on hikes | 21 |
| Spikes the coffee | 17 |
| Spikes the punch | 16 |
| Spikes used by mountain climbers | 32 |
| Spikes with arsenic | 19 |
| Spikes, as a drink | 18 |
| Spikes, as punch | 16 |
| Spikes, e.g. | 12 |
| Spikes, in volleyball | 21 |
| SpikeTV, formerly | 17 |
| Spikey leathermaker's tool? | 31 |
| Spiking | 7 |
| Spiky cuts | 10 |
| Spiky device thrown in the road to puncture a speeding suspect's tires | 74 |
| Spiky device thrown in the road to puncture tires | 49 |
| Spiky grass | 11 |
| Spiky irritant | 14 |
| Spiky plants | 12 |
| Spiky readout: Abbr. | 20 |
| Spiky succulent | 15 |
| Spiky-haired doll | 17 |
| Spile | 5 |
| Spill | 5 |