| Desmudge, as a touchscreen | 26 |
| Desolate land of Siberia | 24 |
| Desolate place, so to speak | 27 |
| DeSoto, Hudson, or LaSalle | 26 |
| Despair's opposite | 22 |
| Desperado of the 19th century | 29 |
| Desperado's weapon | 22 |
| Desperate battlefield cry | 25 |
| Desperate call, for short | 25 |
| Desperate final effort | 22 |
| Desperate housewife Hatcher | 27 |
| Desperate need of Richard III | 29 |
| Desperate TV character? | 23 |
| Desperate, as a situation | 25 |
| Desperate, as a warning | 23 |
| Desperate, as an effort | 23 |
| Desperate, as circumstances | 27 |
| Desperately hanging on | 22 |
| Desperately longing (to) | 24 |
| Desperately needed a shower | 27 |
| Desperately needing a map | 25 |
| Desperately needing rain | 24 |
| Desperately tries to get | 24 |
| Desperation football pass | 25 |
| Desperation gridiron pass | 25 |
| Desperation, of a sort | 22 |
| Despicable person, in slang | 27 |
| Despicable to the nth degree | 28 |
| Despicably cowardly dentist? | 28 |
| Despise the hell out of | 23 |
| Despise with a passion | 22 |
| Despised tax, for short | 23 |
| Despised thing or person | 24 |
| Despite that, informally | 24 |
| Despite the circumstances | 25 |
| Despite the stated objections | 29 |
| Despondent one's color? | 27 |
| Despot overthrown in 2003 | 25 |
| Despot's concession? | 24 |
| Despot's first name | 23 |
| Despotic jurisdictions | 22 |
| Dessert after jambalaya | 23 |
| Dessert akin to boo meringue? | 29 |
| Dessert and fashion words | 25 |
| Dessert at a power lunch? | 25 |
| Dessert at the drive-thru | 25 |
| Dessert at the Orchestral Inn | 29 |
| Dessert brand since 1897 | 24 |
| Dessert cart selection | 22 |
| Dessert chain founded in Ark. | 29 |
| Dessert choice at Wendy's | 29 |
| Dessert choice, perhaps | 23 |
| Dessert course at the prison? | 29 |
| Dessert dipped in coffee | 24 |
| Dessert display vehicle | 23 |
| Dessert eaten with a spoon | 26 |
| Dessert filled with bean curd | 29 |
| Dessert Florida is famous for | 29 |
| Dessert for a chocoholic | 24 |
| Dessert for a court jester? | 27 |
| Dessert for a ruminant? | 23 |
| Dessert for Bill Cosby | 22 |
| Dessert for ice-cream lovers | 28 |
| Dessert for red artisan? | 24 |
| Dessert for the mistaken? | 25 |
| Dessert for the wee set | 23 |
| Dessert in a tall glass | 23 |
| Dessert in paper-thin layers | 28 |
| Dessert in the slammer? | 23 |
| Dessert introduced in 1897 | 26 |
| Dessert item since 1912 | 23 |
| Dessert made with espresso | 26 |
| Dessert made with ladyfingers | 29 |
| Dessert made with mascarpone | 28 |
| Dessert made with molasses | 26 |
| Dessert made with pineapple | 27 |
| Dessert made with sponge cake | 29 |
| Dessert maker's equipment | 29 |
| Dessert maker's work? | 25 |
| Dessert makers' contests | 28 |
| Dessert not made by priests? | 28 |
| Dessert of stewed fruit | 23 |
| Dessert order, perhaps | 22 |
| Dessert served in a bowl | 24 |
| Dessert served in hospitals | 27 |
| Dessert served in wedges | 24 |
| Dessert served with honey | 25 |
| Dessert set with gelatin | 24 |
| Dessert similar to a cobbler | 28 |
| Dessert symbolizing optimism? | 29 |
| Dessert table container | 23 |
| Dessert that sounds like dirt | 29 |
| Dessert wine from Spain | 23 |
| Dessert wine, informally | 24 |
| Dessert with dark streaks | 25 |
| Dessert with ice cream | 22 |
| Dessert with nuts and honey | 27 |
| Dessert, say, to a dieter | 25 |
| Dessert, to Harry Potter | 24 |
| Desserts akin to cobblers | 25 |