| Sitcom star, often | 18 |
| Sitcom star who said "Putting humans in charge of the earth is the cosmic equivalence of letting Eddie Murphy direct" | 127 |
| Sitcom star since 1995 | 22 |
| Sitcom star Romano | 18 |
| Sitcom star Jillian | 19 |
| Sitcom star Delta | 17 |
| Sitcom star busted for pot in 1998 at his home in West Virginia | 63 |
| Sitcom spun off from "The Dukes of Hazzard" | 53 |
| Sitcom spouse | 13 |
| Sitcom sports agent Michaels | 28 |
| Sitcom spender of brandels and grebbels | 39 |
| Sitcom span | 11 |
| Sitcom souse | 12 |
| Sitcom sot | 10 |
| Sitcom since 2009 | 17 |
| Sitcom sign-off word | 20 |
| Sitcom shrink surname | 21 |
| Sitcom showing | 14 |
| Sitcom sewer worker | 19 |
| Sitcom set sight | 16 |
| Sitcom set in Tuckahoe, N.Y. | 28 |
| Sitcom set in the city | 22 |
| Sitcom set in Texas | 19 |
| Sitcom set in Queens | 20 |
| Sitcom set in Ohio | 18 |
| Sitcom set in Norwich, Vt. | 26 |
| Sitcom set in Korea | 19 |
| Sitcom set in Houston | 21 |
| Sitcom set in Hooterville | 25 |
| Sitcom set in Fort Courage | 26 |
| Sitcom set in Cowtown, Texas | 28 |
| Sitcom set in Brooklyn | 22 |
| Sitcom set in Baltimore | 23 |
| Sitcom set in a junkyard | 24 |
| Sitcom set in a garage | 22 |
| Sitcom set in a bookstore | 25 |
| Sitcom set in 1860s Kansas | 26 |
| Sitcom set during the 1860s | 27 |
| Sitcom set at the Sunshine Cab Company | 38 |
| Sitcom set at Mel's Diner | 29 |
| Sitcom set at a Vermont inn | 27 |
| Sitcom sergeant | 15 |
| Sitcom sequence | 15 |
| Sitcom segments | 15 |
| Sitcom segment | 14 |
| Sitcom security device that often defeated its own purpose | 58 |
| Sitcom samples | 14 |
| Sitcom role for Nabors | 22 |
| Sitcom role for Julia | 21 |
| Sitcom role for Brandy Norwood | 30 |
| Sitcom role for Brandy | 22 |
| Sitcom role for Borgnine | 24 |
| Sitcom redhead | 14 |
| Sitcom radio station | 20 |
| Sitcom psychiatrist Frasier, to his patients | 44 |
| Sitcom producer Norman | 22 |
| Sitcom producer | 15 |
| Sitcom precursor | 16 |
| Sitcom POW | 10 |
| Sitcom planet people | 20 |
| Sitcom planet first mentioned in an episode of "Happy Days" | 69 |
| Sitcom planet | 13 |
| Sitcom pioneer Desi | 19 |
| Sitcom pioneer Arnaz | 20 |
| Sitcom pioneer | 14 |
| Sitcom palomino | 15 |
| Sitcom pal of Fred | 18 |
| Sitcom pal of Barbarino and Horshack | 36 |
| Sitcom overseer | 15 |
| Sitcom outtakes | 15 |
| Sitcom originally titled "These Friends of Mine" | 58 |
| Sitcom on which everyone overacts? | 34 |
| Sitcom on the CW | 16 |
| Sitcom oldie, 'Kate & --' | 37 |
| Sitcom of the 70's | 22 |
| Sitcom of the 1990s | 19 |
| Sitcom noncom | 13 |
| Sitcom newsman Baxter | 21 |
| Sitcom named for its star | 25 |
| Sitcom named for its country star | 33 |
| Sitcom mother of Serge and Saffron | 34 |
| Sitcom most famous for "The Puppy Episode" | 52 |
| Sitcom mom since '89 | 24 |
| Sitcom mom of Cheyenne and Kyra | 31 |
| Sitcom mom | 10 |
| Sitcom material | 15 |
| Sitcom marine | 13 |
| Sitcom mail carrier | 19 |
| Sitcom luminary Griffith | 24 |
| Sitcom lover of Chachi | 22 |
| Sitcom legend Alda | 18 |
| Sitcom legend Alan | 18 |
| Sitcom legend | 13 |
| Sitcom landlord Fred | 20 |
| Sitcom landlord | 15 |
| Sitcom king Norman | 18 |
| Sitcom intro music | 18 |
| Sitcom interruptions, sometimes | 31 |
| Sitcom interruption | 19 |
| Sitcom interrupters | 19 |